Homes for sale in Bluffton South Carolina. View MLS listings Bluffton SC for sale. Real estate for sale Bluffton South Carolina MLS listings in Beaufort County SC for sale. View houses, lots, commercial, townhouses, and condos for sale Bluffton SC. Including waterfront homes, marsh front, land, lots, agricultural, hunting land, and deep water properties & real estate. Right next to Beaufort SC real estate, the Bluffton area sits between Hilton Head and Beaufort so it is very convenient to get to both towns.