Lake Marion Santee SC Properties. Waterfront homes for sale on Lake Marion SC. Santee SC lakefront homes for sale Lake Marion in South Carolina. If you’re definitely interested in only the Santee SC area, then you may also want to consider Lake Moultrie homes as well. Surprisingly, Lake Marion has South Carolina lakefront condos in addition to lots and houses on the water for sale. Technically a reservoir Lake Marion offers the convenience of being more or less in the middle between Columbia and Charleston SC, the two largest cities of South Carolina. The makes it an ideal place to purchase a large lakefront on water property. 

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