Lake Moultrie Santee SC Properties for sale. Waterfront homes for sale on Lake Moultrie SC. Santee SC lakefront homes for sale Lake Moultrie in South Carolina. Lake Moultrie in the Santee area of South Carolina is a reservoir about an hour drive to Columbia SC to the north and an hours drive east to the coast in Charleston SC so it’s situated nicely.  The sister adjoining body of water known as Lake Marion is much larger and more well known.  On Lake Marion there are waterfront condos for sale that do not exist yet on Lake Moultrie. 

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